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Cefamandole nafate

CAS No. 42540-40-9

Cefamandole nafate ( Cephamandole nafate | Cefamandole formate sodium )

产品货号. M19801 CAS No. 42540-40-9

头孢孟多钠是第二代广谱头孢菌素抗生素。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
25MG ¥324 有现货
100MG ¥640 有现货
500MG ¥1272 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Cefamandole nafate
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    头孢孟多钠是第二代广谱头孢菌素抗生素。
  • 产品描述
    Cefamandole nafate is a second-generation broad-spectrum cephalosporin antibiotic.(In Vitro):Cefamandole nafate is shown to be rapidly converted to cefamandole in bacteriological media, with a half-life of less than 1 h at a pH of 7.0 or above. At pH 6.0, in log-phase inhibition experiments, however, Cefamandole nafate is more stable, allowing delineation of the activity between cefamandole and cefamandole nafate.(In Vivo):The toxicity of Cefamandole nafate administered iv Is studied in rats receiving doses of 250-1,000 mg/kgfive days per week for one month.After the administration of Cefamandole nafate for one month, there are no treatment-related adverse effects on growth, food consumption, clinical chemistry, hematology, or organ weights.
  • 体外实验
    Cefamandole nafate is shown to be rapidly converted to cefamandole in bacteriological media, with a half-life of less than 1 h at a pH of 7.0 or above. At pH 6.0, in log-phase inhibition experiments, however, Cefamandole nafate is more stable, allowing delineation of the activity between cefamandole and cefamandole nafate.
  • 体内实验
    The toxicity of Cefamandole nafate administered iv Is studied in rats receiving doses of 250-1,000 mg/kg five days per week for one month.After the administration of Cefamandole nafate for one month, there are no treatment-related adverse effects on growth, food consumption, clinical chemistry, hematology, or organ weights.
  • 同义词
    Cephamandole nafate | Cefamandole formate sodium
  • 通路
    GPCR/G Protein
  • 靶点
    Antibacterial
  • 受体
    Bacterial
  • 研究领域
    Inflammation/Immunology
  • 适应症
    Pulmonary infection urinary tract infection biliary tract infection skin and soft tissue infection bone and joint infection

化学信息

  • CAS Number
    42540-40-9
  • 分子量
    512.49
  • 分子式
    C19H17N6NaO6S2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥ 41 mg/mL (80.00 mM);Water:≥ 29 mg/mL (56.59 mM)
  • SMILES
    [Na+].Cn1nnnc1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](OC=O)c1ccccc1)C2=O)C([O-])=O
  • 化学全称
    sodium;(6R7R)-7-[[(2R)-2-formyloxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Taha M. et al.: Bioorg. Med. Chem. 16 1218 (2008)
产品手册
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